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In this analysis, we noted that the two primarily enriched transcription factors were ATF4 and XBP1, both linked to endoplasmic reticulum stress and the unfolded protein response (Fig S1C)

This research validates the physical reality of "brain fog" and cognitive dysfunction, showing it is not a psychological symptom but a direct result of localized antioxidant depletion and cellular energy failure

The human evidence is limited, but the mechanistic rationale is enough that this remains an active research area

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